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In patients identified as having iron deficiency anemia microcytic anemia following gastric bypass surgery, coadministration of vitamin C with iron supplementation can increase the conversion of iron to its absorbable form by reducing the pH of the stomach.
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This study, funded by drug maker GlaxoSmithKline, was also published simultaneously June 4 in the New England Journal of Medicine.
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The recommended total daily dose of ketorolac tromethamine tablets (maximum 40 mg) is significantly lower than for ketorolac tromethamine injection (maximum 120 mg).
Hypovolemia should be corrected prior to the administration of TORADOL (see WARNINGS: Renal Effects).
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The absorption of ketorolac is rapid, Cmax being attained between 20 to 60 min.
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Electrical stimulation of peripheral nerves may influence pain inhibitory pathways, inhibit substance-P release, and perhaps cause the release of endogenous opiate substances ().
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In the emergency department, ketorolac attenuates moderate to severe pain in patients with renal colic, migraine headache, musculoskeletal pain or sickle cell crisis and is usually as effective as frequently used opioids, such as morphine and pethidine, and other NSAIDs and analgesics.
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